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Gene Editing of Large Mammals
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Animal Science".
Deadline for manuscript submissions: 22 April 2022.
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Special Issue Editors

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Special Issue Information
Dear Colleagues,
Genome editing technologies can be used to precisely alter genomic sequences and modify the genetic information at specific target sites of an organism. Compared with the long breeding cycle and high cost of traditional genetic breeding, gene editing can be used to implement cost-effective targeted editing of animal genomes, thereby providing a powerful application tool for rapid improvement of the production traits of large mammals. In addition, some large mammals are closely related to human beings. These gene-edited large mammals can serve as a disease model, animal bioreactor, or be used in xenotransplantation. However, the application of gene editing to generate gene-edited large mammals is still in a stage of significant development. To stimulate progress on this topic, this Special Issue aims to cover the following non-exhaustive areas of relevance:
The application of gene editing to large mammals and the successful generation of mutants;
How to improve gene editing efficiency in large animals;
Developing disease models using gene-editing technology;
Application of novel gene-editing techniques in xenotransplantation, animal bioreactor and humanized organ research.
Dr. Zhengxing Lian
Dr. Shoulong Deng
Dr. Xuguang Du
Guest Editors
Manuscript Submission Information
Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
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Keywords