多动症|朋友多的人有什么能力缺陷?熬夜对多动症的伤害更大?( 三 )


结果发现,①不管是野生组还是带有阿尔茨海默症致病基因组的老年大鼠(22个月),均都出现低学习和记忆能力;②但有趣的是,转基因大鼠在8月大时在场景转换、莫里斯水迷宫中就表现出了行为不灵活现象,而野生大鼠在13个月或者22个月才出现行为不灵活现象;③而且神经检查发现,8月、13月大的转基因大鼠胼胝体内小胶质细胞的激活数量分别与13月、22月大的野生大鼠相似;④在较老的转基因大鼠中,记忆和学习障碍过于明显,以至于出现行为更不灵活现象 。
以上的结果均表明在正常大鼠衰老中出现的行为不灵活和白质炎症,在AD大鼠中均提前到来,并且先于学习和记忆障碍的出现 。
或许这一结果可以给人类老年痴呆症研究带来启示,如果您也在步入老年之前出现行为不灵活现象,可能得多加检查,预防会延迟老年痴呆症的出现 。
参考文献:
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[3] Faria A , Rojek-Giffin M , Gross J , et al. Social Preferences Correlate with Cortical Thickness of the Orbito-Frontal Cortex[J]. Social Cognitive and Affective Neuroscience, 2021.
[4] Cohen A, Asraf K, Saveliev I, et al. The effects of sleep deprivation on the processing of emotional facial expressions in young adults with and without ADHD[J]. Scientific Reports, 2021, 11(1): 1-11.
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